Interaction guide
Supplements and Medicines: Interactions to Check Before You Start
Supplements and medicines can interact, even when both are sold without a prescription. HoneyPezil lists arginine, which can add to the effect of nitrates, erection medicines and blood pressure medicine, and niacin, which interacts with two tuberculosis medicines. Show the bottle to your pharmacist and keep taking prescribed medicine as directed.
- Ask first ifYou take nitrates or BP medicine
- Arginine linesAt most 400 mg a capsule
- NeverStop a medicine on your own
Written by the HoneyPezil label deskUpdated
The basics01
Can supplements interact with medicines?
Yes, supplements can interact with medicines. The National Center for Complementary and Integrative Health says supplements may interact with your medications, and some may raise bleeding risk or affect anesthesia (NCCIH, Using Supplements Wisely).
The NIH Office of Dietary Supplements adds that "natural" does not always mean safe, and that supplements do not need FDA approval before sale (NIH ODS, What You Need to Know).
Tell every provider what you take, read the label, and ask a pharmacist before you add something new. Never stop a prescribed medicine on your own because of a supplement.
The HoneyPezil label02
Which HoneyPezil ingredients can interact with medicines?
The arginine lines and niacin are the ones to check. HoneyPezil lists L-arginine 200 mg and L-arginine AKG 200 mg, which means at most 400 mg of arginine ingredients per capsule, plus niacin 7.5 mg NE.
Mayo Clinic lists arginine interactions with blood pressure medicine, nitrates and sildenafil, blood thinners, diabetes medicine and potassium-sparing diuretics (Mayo Clinic, L-arginine). NIH lists niacin interactions with the tuberculosis medicines isoniazid and pyrazinamide (NIH ODS, Niacin).
Studies used far larger amounts than the capsule holds, and no source tested 400 mg. We cannot say the capsule has these effects. The cautions are listed for the ingredient, so ask before you start.
| If you take | Label line involved | Why it is listed |
|---|---|---|
| Nitrates for chest pain, or an erection medicine | Arginine | Blood pressure may fall too low (Mayo Clinic, L-arginine) |
| Blood pressure medicine | Arginine | Arginine lowered pressure a few points at 4 g a day or more (Shiraseb 2022, Arginine and blood pressure) |
| Diabetes medicine or insulin | Arginine | Blood sugar may fall (Mayo Clinic, L-arginine) |
| Blood thinner or aspirin | Arginine | Bleeding risk is listed (Mayo Clinic, L-arginine) |
| Potassium-sparing diuretic | Arginine | Potassium may run high (Mayo Clinic, L-arginine) |
| Isoniazid or pyrazinamide | Niacin | NIH lists an interaction (NIH ODS, Niacin) |
Try it03
How do you check your own medicines against the label?
Tick what applies to you in the checker below to see which label lines matter and why. It is a conversation starter for your pharmacist and not a clearance.
Nothing ticked. Still read the label warnings and tell your doctor about every supplement you take.
- Nitrates for chest pain, or erection medicines such as sildenafil or tadalafilL-arginine (base) · L-arginine AKG 2:1 extract
Arginine can lower blood pressure, and these medicines do too. Nitrates must not be combined with erection medicines, so a doctor should know everything you take. Ask your doctor or pharmacist first. (Mayo Clinic, L-arginine) (StatPearls, Nitrates and erection medicines)
- Blood pressure medicineL-arginine (base) · L-arginine AKG 2:1 extract · L-citrulline HCl · L-citrulline malate
Arginine lowered blood pressure in trials at gram doses, and citrulline analyses disagree. No source tested 400 mg or 200 mg, but ask your doctor before you start. (Mayo Clinic, L-arginine) (Shiraseb 2022, Arginine and blood pressure)
- A heart attack in the past, or heart diseaseL-arginine (base) · L-arginine AKG 2:1 extract
Mayo says arginine is not recommended after a heart attack, and a trial after a heart attack saw deaths in the arginine group. Ask your cardiologist first. (Mayo Clinic, L-arginine) (Schulman 2006, Arginine after a heart attack)
- Diabetes medicine or insulinL-arginine (base) · L-arginine AKG 2:1 extract · Niacin
Arginine may lower blood sugar, and high-dose nicotinic acid can raise it. Check with your doctor and watch your readings. (Mayo Clinic, L-arginine) (NIH ODS, Niacin)
- Blood thinner or daily aspirinL-arginine (base) · L-arginine AKG 2:1 extract
Mayo lists a possible bleeding risk with arginine. Ask before you start, and tell your surgeon or dentist. (Mayo Clinic, L-arginine)
- A potassium-sparing diureticL-arginine (base) · L-arginine AKG 2:1 extract
Mayo lists a caution for arginine with potassium-sparing diuretics. Ask your pharmacist. (Mayo Clinic, L-arginine)
- Isoniazid or pyrazinamide (tuberculosis medicines)Niacin
The NIH lists interactions between niacin and these medicines. Ask your pharmacist. (NIH ODS, Niacin)
- Gout, asthma or allergyL-arginine (base) · L-arginine AKG 2:1 extract
Mayo lists gout, allergy and asthma worsening among arginine's effects. Ask your doctor first. (Mayo Clinic, L-arginine)
- A medicine you think may affect your memory
NIA and Mayo both say some medicines can cause forgetfulness or confusion. Do not stop a medicine on your own. Ask the prescriber or your pharmacist to review the list, supplements included. (NIA, Cognitive health and older adults) (Mayo Clinic, Memory loss: when to seek help)
- Surgery in the next two weeks
Supplements can raise bleeding risk or affect anesthesia, so tell your surgeon about every supplement well before surgery. (NCCIH, Using Supplements Wisely)
A teaching aid, not medical advice, and not a full list of interactions. Your pharmacist can check your exact medicines.
Heart and blood pressure04
Is arginine a concern after a heart attack or with nitrates?
It can be. Mayo Clinic says arginine is not recommended after a recent heart attack, and it lists nitrates and sildenafil among the medicines that can combine with arginine to drop blood pressure too low (Mayo Clinic, L-arginine).
A trial of arginine after a heart attack was stopped after deaths in the arginine group. It used gram doses well above this label, and it does not show what a 200 mg line does (Schulman 2006, Arginine after a heart attack). Nitrates and erection medicines are also not allowed together, so your doctor should know everything you take (StatPearls, Nitrates and erection medicines).
Chest pain, shortness of breath, a drooping face, weak arm, slurred speech or sudden confusion: call 911 right away (CDC, Stroke signs and symptoms) (CDC, Heart attack signs).
HoneyPezil: 2, 3 or 6 bottles30 capsules a bottle · 30 days at 1 a day · 60-day money-back guarantee
See packsSay the name clearly05
Why show your pharmacist the HoneyPezil bottle?
Showing the bottle prevents mix-ups. HoneyPezil is a dietary supplement, not a drug, but the name sounds like some prescription names, and look-alike names are a known cause of errors (FDA, Proprietary names guidance).
Spell it out: H-o-n-e-y-P-e-z-i-l. Hand over the bottle with the Supplement Facts showing, so the pharmacist can read the real ingredients. Our name confusion page has more.
Also ask about timing. The label says one capsule daily, or as directed by your healthcare professional, so your pharmacist can advise how to space it from other medicines.
If something goes wrong06
What should you do if a supplement causes a bad reaction?
Stop and get medical help if a reaction is serious, then report it. The FDA runs MedWatch, a safety reporting program where people can report a bad reaction to a dietary supplement (FDA, MedWatch).
For a milder reaction, call your doctor or pharmacist before you take another capsule. Tracking and refunds on placed orders go through Order desk. More on side effects and who it is for.
FAQ07
HoneyPezil questions people ask
Can I take supplements with prescription medicine?
Sometimes, but not always. NCCIH says supplements may interact with medications. Tell your doctor and pharmacist about every supplement, and keep taking prescribed medicine exactly as directed. Never stop a medicine because of a supplement.
Does arginine interact with blood pressure medicine?
Mayo Clinic lists blood pressure medicine among the drugs that can interact with arginine, because pressure may drop too low. HoneyPezil has at most 400 mg of arginine ingredients per capsule. Ask your doctor or pharmacist first.
Can I take HoneyPezil with nitrates?
Ask your doctor or pharmacist before you do. Mayo Clinic says arginine can combine with nitrates to drop blood pressure too low. No source tested the amount in one capsule, but the caution is listed for the ingredient.
Does niacin interact with any medicine?
NIH lists interactions between niacin and the tuberculosis medicines isoniazid and pyrazinamide. HoneyPezil has 7.5 mg NE of niacin per capsule, and the label does not say which form. Ask your pharmacist if you take either medicine.
Should I stop a medicine if I start a supplement?
No. Keep taking prescribed medicine exactly as directed. If you think a supplement and a medicine clash, call the prescriber or a pharmacist before changing anything.
Who wrote this08
Written and reviewed by
Pages built from the label, the brand panels and linked NIH, FDA, CDC, FTC and peer-reviewed sources.
Last updated . Read our editorial standards and how we check reviews. This website is the information site for a U.S. stocking partner for HoneyPezil. It is not the manufacturer or the distributor named on the label. We earn money when you buy through our order links.
Keep reading
More about HoneyPezil
U.S. stocking partner for HoneyPezil
Ready to try HoneyPezil?
Check your medicines first, especially nitrates, erection medicines and blood pressure medicine, then pick a pack. One bottle is 30 days at 1 capsule a day; 3 bottles cover 90 days and 6 cover 180. A supplement does not replace a doctor's visit for memory trouble that lasts.
- Secure checkout
- 60-day money-back guarantee
- Ships from the U.S. with tracking
